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Haemostasis research

The Haemostasis Laboratory and The Platelet Laboratory have been active in the research of thrombosis and bleeding disorders for decades. We have published a number of original scientific articles in high impact international medical journals. At present our research interest lies in the neonatal alloimmune thrombocytopenia, and project collaborations in the field of haemostasis.

Contacts

Haemostasis

Leena Hiltunen, MD, PhD; leena.hiltunen(at)bloodservice.fi

Outi Huoponen, MSci, laboratory specialist; outi.huoponen(at)bloodservice.fi

Platelet disorders

Susanna Sainio, MD, PhD, adjunct professor; susanna.sainio(at)bloodservice.fi

Satu Kärkkäinen, PhD, laboratory specialist; satu.kärkkäinen(at)bloodservice.fi

Recent publications

Kuitunen A, Sinisalo M, Vahtera A, Hiltunen L, Javela K, Laine O. Autoimmune heparin-induced thrombocytopenia of delayed onset: a clinical challenge. Transfusion. 2018 Oct 4. doi: 10.1111/trf.14814. [Epub ahead of print] PubMed PMID: 30284726.

Lokki AI, Kaartokallio T, Holmberg V, Onkamo P, Koskinen L, Saavalainen P, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Villa P, Hiltunen L, Laivuori H, Meri S. Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia. Frontiers in Immunology 2017;8(article589). PMID: 28611769

Sainio S, Javela K, Tuimala J, Haimila K. Maternal HLA genotyping is not useful for predicting severity of fetal and neonatal alloimmune thrombocytopenia. British Journal of Haematology 2017;176(1):111-7. PMID: 27748520

Vepsäläinen K, Lassila R, Arola M, Huttunen P, Koskinen S, Ljung R, Lähteenmäki P, Möttönen M, Riikonen P. Inhibitor development in previously untreated patients with severe haemophilia A: a nationwide multicentre study in Finland. Haemophilia. 2016;22(5):721-9. PMID: 27339837.

Kaartokallio T, Lokki AI, Peterson H, Kivinen K, Hiltunen L, Salmela E, Lappalainen T, Maanselkä P, Heino S, Knuutila S, Sayed A, Poston L, Brennecke SP, Johnson MP, Morgan L, Moses EK, Kere J, Laivuori H. Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes. Ann Med. 2016;48(5):330-6. PMID: 27111527.

Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G. Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia. Br J Haematol. 2016;174(2):310-20. doi:10.1111/bjh.14053. PubMed PMID: 27017954.

Javela K. Hemostaasitutkimusten preanalytiikka. Moodi 2015;38(1):22-23.

Möttönen M, Hiltunen L, Rajantie J, Juntti H, Mäkipernaa A. Transient hemorrhagic diathesis caused by prothrombin-binding antiphospholipid antibody in a child. Duodecim. 2014;130(20):2108-11. PMID: 25558609.

Parkkonen O, Mustonen P, Puurunen M, Valkonen K, Nieminen M, Sinisalo J: Coagulation changes in takotsubo cardiomyopathy support acute phase reaction and catecholamine excess, but not thrombus production. International Journal of Cardiology 2014;177(3):1063-1065. PMID: 25465840

Hiltunen L, Uotila J. Thrombophilia and pregnancy. Duodecim. 2014;130(17):1700-7. Review. PMID: 25272781.

Mustonen P, Lehtonen KV, Javela K, Puurunen M. Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study. Lupus. 2014;23(14):1468-76. PMID: 25164304.

Bäckman S, Javela K, Koivusalo AM, Isoniemi H, Halme M, Hämmäinen P, Koskinen S. Successful liver and lung transplantation in patients with severe IgA deficiency, high anti-IgA concentration and a history of anaphylactic transfusion reaction. Transfus Med. 2014;24(4):251-3. PMID: 25066101.

Bäckman S, Hiltunen L, Huoponen O, Vepsäläinen K, Riikonen P. Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo. Int J Lab Hematol. 2014;36(5) PMID: 24495303.

Puurunen M, Salo P, Engelbarth S, Javela K, Perola M. Type II antithrombin deficiency caused by a founder mutation Pro73Leu in the Finnish population: clinical picture. J Thromb Haemost. 2013;11(10):1844-9. PMID: 23910795.

Javela K, Engelbarth S, Hiltunen L, Mustonen P, Puurunen M. Great discrepancy in antithrombin activity measured using five commercially available functional assays. Thromb Res. 2013;132(1):132-7. PMID: 23768451.

Tiller H, Kamphuis MM, Flodmark O, Papadogiannakis N, David AL, Sainio S, Koskinen S, Javela K, Wikman AT, Kekomaki R, Kanhai HH, Oepkes D, Husebekk A, Westgren M. Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. BMJ Open. 2013;3(3). PMID: 23524102.

Sainio S, Javela K, Tuimala J, Koskinen S. Usefulness of maternal anti-HPA-1a antibody quantitation in predicting severity of foetomaternal alloimmune thrombocytopenia. Transfus Med. 2013;23(2):114-20. PMID: 23448161.