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Haemostasis research

The Haemostasis Laboratory has been active in the research of thrombosis and bleeding disorders for decades. We have published a number of original scientific articles in high impact international medical journals.

At present our research interest lies in the clinical picture, laboratory diagnosis and genetics of rare heritable and acquired thrombophilias and neonatal autoimmune thrombocytopenia. We are also interested in project collaborations with other research groups in the field of haemostasis.

Recent publications

Mustonen P, Lehtonen KV, Javela K, Puurunen M. Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study. Lupus. 2014;23(14):1468-76. PM: 25164304.

Bäckman S, Hiltunen L, Huoponen O, Vepsäläinen K, Riikonen P. Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo. Int J Lab Hematol. 2014;36(5) PM: 24495303.

Bäckman S, Javela K, Koivusalo AM, Isoniemi H, Halme M, Hämmäinen P, Koskinen S. Successful liver and lung transplantation in patients with severe IgA deficiency, high anti-IgA concentration and a history of anaphylactic transfusion reaction. Transfus Med. 2014;24(4):251-3. PM: 25066101.

Möttönen M, Hiltunen L, Rajantie J, Juntti H, Mäkipernaa A. Transient hemorrhagic diathesis caused by prothrombin-binding antiphospholipid antibody in a child. Duodecim. 2014;130(20):2108-11. PM: 25558609.

Hiltunen L, Uotila J. Thrombophilia and pregnancy. Duodecim. 2014;130(17):1700-7. Review. PM: 25272781.

Puurunen M, Salo P, Engelbarth S, Javela K, Perola M. Type II antithrombin deficiency caused by a founder mutation Pro73Leu in the Finnish population: clinical picture. J Thromb Haemost. 2013;11(10):1844-9. PM: 23910795 .

Javela K, Engelbarth S, Hiltunen L, Mustonen P, Puurunen M. Great discrepancy in antithrombin activity measured using five commercially available functional assays. Thromb Res. 2013;132(1):132-7. PM: 23768451.

Tiller H, Kamphuis MM, Flodmark O, Papadogiannakis N, David AL, Sainio S, Koskinen S, Javela K, Wikman AT, Kekomaki R, Kanhai HH, Oepkes D, Husebekk A, Westgren M. Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry. BMJ Open. 2013;3(3). PM: 23524102 .

Sainio S, Javela K, Tuimala J, Koskinen S. Usefulness of maternal anti-HPA-1a antibody quantitation in predicting severity of foetomaternal alloimmune thrombocytopenia. Transfus Med. 2013;23(2):114-20. PM: 23448161.

Bertrand G, Bakchoul T, Javela K, Kjaer Killie M, Kaplan C; SSC of the ISTH. Interlaboratory workshop on anti-HPA-1a alloantibody quantification with the mAb-specific immobilization of platelet antigen technique. J Thromb Haemost. 2012;10(6):1172-4. PM: 22826827.

Ferreira RC, Pan-Hammarström Q, Graham RR, Fontán G, Lee AT, Ortmann W, Wang N, Urcelay E, Fernández-Arquero M, Núňez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Padyukov L, Gregersen PK, Hammarström L, Behrens TW. High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency. PLoS Genetics 2012;8(1):1-12. PM: 22291608.

Lokki AI, Klemetti MM, Heino S, Hiltunen L, Heinonen S, Laivuori H. Association of the rs1424954 polymorphism of the ACVR2A gene with the risk of pre-eclampsia is not replicated in a Finnish study population. BMC Res Notes. 2011;4:545. PM: 22177086

Klemetti M, Hiltunen LM, Heino S, Heinonen S, Kajantie E, Laivuori H. An obesity-related FTO variant and the risk of preeclampsia in a Finnish study population. J Pregnancy. 2011;2011:251470. PM: 22132335.

Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, Rasi V, Paunio M. Factor V Leiden as a risk factor for preterm birth--a population-based nested case-control study. J Thromb Haemost. 2011;9(1):71-8. PM: 20946152.

Ranta S, Koskinen S, Mäkipernaa A. Successful eradication of inhibitor of late recurrence and other high risk prognostic factors in a patient with severe haemophilia A. Haemophilia. 2011;17(5):e833-4. PM: 21624011.

Bettelheim D, Panzer S, Reesink HW, Csapo B, Pessoa C, Guerra F, Wendel S, Calda P, Sprogøe U, Dziegiel M, Aitokallio-Tallberg A, Koskinen S, Kuosmanen M, Legler TJ, Stein W, Villa S, Villa MA, Trespidi L, Acaia B, Vandenbussche FP, Brand A, de Haas M, Kanhai HH, Gounder D, Flanagan P, Donegan R, Parry E, Sefonte C, Skulstad SM, Hervig T, Flesland Ø, Zupańska B, Uhrynowska M, Lapaire O, Zhong XY, Holzgreve W. Monitoring and treatment of anti-D in pregnancy. Vox Sang. 2010;99(2):177-92. PM:  20331536.

Hiltunen LM, Laivuori H, Rautanen A, Kaaja R, Kere J, Krusius T, Paunio M, Rasi V.Factor V Leiden as risk factor for unexplained stillbirth--a population-based nested case-control study. Thromb Res. 2010;125(6):505-10. PM: 19828176.

Ferreira RC, Pan-Hammarström Q, GrahamRR, Gateva V, Fontán G, Lee AT, OrtmannW, Urcelay E, Fernández-Arquero M, Núñez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Clark HF, Klareskog L, Gregersen PK, Behrens TW & Hammarström L. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet.2010;42(9):777-80. PM: 20694011.

Javela K, Kekomäki R, Koskinen S. Significance of quantitative measurement of heparin-induced platelet antibodies. Eur J Haematol. 2010;84(2):169-74. PM: 19845741.