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Articles 2019

Grau-Vorster M, Laitinen A, Nystedt J, Vives J. HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study. Stem Cell Research & Therapy 2019 Jun 13;10(1):164. PMID: 31196185

Holopainen M, Colas RA, Valkonen S, Tigistu-Sahle F, Hyvärinen K, Mazzacuva F, Lehenkari P, Käkelä R, Dalli J, Kerkelä E, Laitinen S. Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun 15;1864(10):1350-1362. PMID: 31207356

Jahnukainen T, Lauronen J, Raissadati A, Pihkala J, Ylinen E, Puntila J, Salminen JT, Pätilä T, Mattila IP, Jalanko H. Development of human leukocyte antigen antibodies against vascular homograft donor in pediatric heart transplant recipients. Ann Transplant. 2019 Aug 6;24:454-460. PMID: 31383839

Kivelä JM, Lempinen M, Holmberg C, Jalanko H, Pakarinen MP, Isoniemi H, Lauronen J. Renal function after combined liver-kidney transplantation: A longitudinal study of pediatric and adult patients. Pediatr Transplant. 2019 Jun;23(4):e13400. PMID: 30938071

Linjama T, Räther C, Ritari J, Peräsaari J, Eberhard HP, Korhonen M, Koskela S. Extended HLA Haplotypes and Their Impact on DPB1 Matching of Unrelated HSCT Donors. Biol Blood Marrow Transplant. 2019 Oct;25(10):1956-1964. PMID: 31306777

Lobier M, Castrén J, Niittymäki P, Palokangas E, Partanen J, Arvas M. The effect of donation activity dwarfs the effect of lifestyle, diet and targeted iron supplementation on blood donor iron stores. PLoS One. 2019 Aug 13;14(8):e0220862. PMID: 31408501

Lobier M, Niittymäki P, Nikiforow N, Palokangas E, Larjo A, Mattila P, Castrén J, Partanen J, Arvas M. FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors. Vox Sang. 2019 Epub 28th Oct. PMID: 31657023

Oja S, Kaartinen T, Ahti M, Korhonen M, Laitinen A, Nystedt J. The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes. Front Immunol. 2019 Jul 16;10:1627. PMID: 31379832

Peltonen T & Ihalainen J. Evaluating Blockchain for the Governance of the Plasma Derivatives Supply Chain: How Distributed Ledger Technology Can Mitigate Plasma Supply Chain Risks. Blockchain in Healthcare Today. 2019, 2.

Raivola V, Snell K, Helén I, Partanen J. Attitudes of blood donors to their sample and data donation for biobanking. Eur J Hum Genet. 2019 Nov;27(11):1659-1667. PMID: 31147625

Ritari J, Hyvärinen K, Koskela S, Niittyvuopio R, Nihtinen A, Salmenniemi U, Putkonen M, Volin L, Kwan T, Pastinen T, Itälä-Remes M, Partanen J. Computational analysis of HLA-presentation of non-synonymous recipient mismatches indicates effect on the risk of chronic graft-versus-host disease after allogeneic HSCT. Front Immunol. 2019 Jul 16;10:1625. PMID: 31379830

Rygård SL, Grønlykke L, Perner A, Winkel P, Lange T, Broksø Holst L, Johansson PI, Aneman A, Brodersen T, Laurén E, Ullum H, Wetterslev J. Storage time of red blood cells among ICU patients with septic shock. Acta Anaesthesiol Scand. 2019 Nov;63(10):1366-1377. PMID: 31283834

Rytkönen S, Ritari J, Peräsaari J, Saarela V, Nuutinen M, Jahnukainen T. IL-10 polymorphisms +434T/C, +504G/T, and -2849C/T may predispose to tubulointersititial nephritis and uveitis in pediatric population. PLoS One. 2019 Feb 19;14(2):e0211915. PMID: 30779760

Salmenkari H, Laitinen A, Forsgård RA, Holappa M, Lindén J, Pasanen L, Korhonen M, Korpela R, Nystedt J. The use of unlicensed bone marrow-derived platelet lysate-expanded mesenchymal stromal cells in colitis: a pre-clinical study. Cytotherapy. 2019 Feb;21(2):175-188. PMID: 30611671,

Salonius E, Kontturi L, Laitinen A, Haaparanta AM, Korhonen M, Nystedt J, Kiviranta I, Muhonen V. Chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells in a three-dimensional environment. J Cell Physiol. 2019 Epub Sep 25. PMID: 31552691

Seppälä LK, Vettenranta K, Pitkäniemi J, Hirvonen E, Leinonen MK, Madanat-Harjuoja LM. Maternal Diabetes and Risk of Childhood Cancer in the Offspring. Int J Cancer. 2019 Epub Oct 28. PMID: 31658368

Valkonen S, Mallas B, Impola U, Valkeajärvi A, Eronen J, Javela K, Siljander P, Laitinen S. Assessment of time-dependent platelet activation using extracellular vesicles, CD62P exposure, and soluble glycoprotein V content of platelet concentrates with two different platelet additive solutions. Transfus Med Hemother. 2019 46:267–275. PMID: 31700509

Valkonen S, Holopainen M, Colas RA, Impola U, Dalli J, Käkelä R, Siljander PR, Laitinen S. Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1168-1182. PMID: 30980920

Van Remoortel H, Aranko K, Müller M, De Buck E, Devine D, Meybohm P, Tiberghien P, Wood E, Vanderkerckhove P, Seifried E. The systematic use of evidence-based methodologies and technologies enhances shared decision-making in the 2018 International Consensus Conference on Patient Blood Management. Vox Sang. 2019. Epub Nov 10. PMID: 31709562


Ilmakunnas M & Sainio S. Kenelle O RhD -negatiivisia punasoluja? Duodecim 2019;135(3):229-31.

Siljander P, Valkonen S, Laitinen S, Kerkelä E. Verisolujen solunulkoiset vesikkelit. Duodecim 2019;135:663–71.

Raivola V. The gift of life – does it apply to donation for research? ISBT Science Series 2019 0, 1–8. Epub 25 Oct.


Irving A, Higgins A, Ady B, Bellomo R, Cooper DJ, French C, Gantner D, Harris A, Irving DO, Murray L, Nichol A, Petrie D, McQuilten ZK; Standard Issue Transfusion versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Investigators and Australian and New Zealand Intensive Care Society Clinical Trials Group. Fresh Red Cells for Transfusion in Critically Ill Adults: An Economic Evaluation of the Standard Issue Transfusion Versus Fresher Red-Cell Use in Intensive Care (TRANSFUSE) Clinical Trial. Crit Care Med. 2019 Jul;47(7):e572-e579. PMID: 31008734