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Articles 2020

Adnan AS, Dufva O, Ianevski A, Ghimire B, Koski J, Maliniemi P, Thomson D, Schreiber A, Heckman CA, Koskenvesa P, Korhonen M, Porkka K, Branford S, Aittokallio T, Kankainen M, Mustjoki S. RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses. Leukemia. 2020 Aug 11. Epub ahead of print. PMID: 32782381

Bäckman S, Valkeajärvi A, Korkalainen P, Arvas M, Castrén J. Venous sample is superior to repeated skin-prick testing in blood donor haemoglobin second-line screening. Vox Sang. 2020 Epub Apr 20. PMID: 32314403

Holopainen M, Impola, U, Lehenkari, P, Laitinen S, Kerkelä, E. Human Mesenchymal Stromal Cell Secretome Promotes the Immunoregulatory Phenotype and Phagocytosis Activity in Human Macrophages. Cells 2020 Sep 22;9(9):E2142. PMID: 32972000  

Hyvärinen K, Koskela S, Niittyvuopio R, Nihtinen A, Volin L, Salmenniemi U, Putkonen M, Buno I, Gallardo D, Itälä-Remes M, Partanen J, Ritari J. Meta-analysis of genome-wide association and gene expression studies implicates donor T cell function and cytokine pathways in acute GvHD. Front Immunol. 2020 Feb 3;11:19. PMID: 32117222

Jalanka J, Cheng J, Hiippala K, Ritari J, Salojärvi J, Ruuska T, Kalliomäki M, Satokari R. Colonic Mucosal Microbiota and Association of Bacterial Taxa with the Expression of Host Antimicrobial Peptides in Pediatric Ulcerative Colitis. Int J Mol Sci. 2020;21(17):E6044. PMID: 32842596

Jokiniemi A, Kuusipalo L, Ritari J, Koskela S, Partanen J, Kekäläinen J. Gamete-level immunogenetic incompatibility in humans-towards deeper understanding of fertilization and infertility? Heredity (Edinb). 2020 Epub Aug 3. PMID: 32747723

Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J, Kekäläinen J. Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function. Proc Biol Sci. 2020;287(1933):20201682. PMID: 32811307

Koponen A, Kerkelä E, Rojalin T, Lázaro-Ibáñez E, Suutari T, Saari HO, Siljander P, Yli-Perttula M, Laitinen S, Viitala T. Label-Free Characterization and Real-Time Monitoring of Cell Uptake of Extracellular Vesicles. Biosens Bioelectron. 2020 Aug 15;168:112510. PMID: 32877783

Lehtisalo M, Keskitalo JE, Tornio A, Lapatto-Reiniluoto O, Deng F, Jaatinen T, Viinamäki J, Neuvonen M, Backman JT, Niemi M. Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin. Clin Transl Sci. Epub 2020 May 26. PMID: 32453913

Partanen J, Hyvärinen K, Bickeböller H, Bogunia-Kubik K, Crossland RE, Ivanova M, Perutelli F, Dressel R. Review of genetic variation as a predictive biomarker for chronic Graft-versus-Host-Disease after allogeneic stem cell transplantation. Front Immunol. 2020 Accepted for publication.

Ritari J, Hyvärinen K, Clancy J, Partanen J, Koskela S. Increasing accuracy of HLA imputation by a population-specific reference panel in a FinnGen biobank cohort. NAR: Genomics and Bioinformatics. 2020 2(2). https://academic.oup.com/nargab/article/2/2/lqaa030/5831010?guestAccessKey=09ab3b5a-fbb5-40a7-9d92-d9ad4a728597

Tammi SM, Tounsi WA, Sainio S, Kiernan M, Avent ND, Madgett TE, Haimila K. Next-generation sequencing of 35 RHD variants in 16,253 serologically D negative pregnant women in Finnish population. Blood Adv. 2020 4(20):4994–5001. https://doi.org/10.1182/bloodadvances.2020001569

Tarvonen M, Hovi P, Sainio S, Vuorela P, Andersson S, Teramo K. Intrapartum zigzag pattern of fetal heart rate is an early sign of fetal hypoxia: a large obstetric retrospective cohort study. Acta Obstet Gynecol Scand. 2020 Sep 27. Epub ahead of print. PMID: 32981037

Zalpuri S, Romeijn B, Allara E, Goldman M, Kamel H, Gorlin J, Vassallo R, Grégoire Y, Goto N, Flanagan P, Speedy J, Buser A, Kutner JM, Magnussen K, Castrén J, Culler L, Sussmann H, Prinsze FJ, Belanger K, Compernolle V, Tiberghien P, Cardenas JM, Gandhi MJ, West KA, Lee CK, James S, Wells D, Sutor LJ, Wendel S, Coleman M, Seltsam A, Roden K, Steele WR, Bohonek M, Alcantara R, Di Angelantonio E, van den Hurk K; BEST Collaborative Study Group. Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates: a BEST Collaborative study. Transfusion. 2020 Mar;60(3):544-552. PMID: 32034925

Konsortium-artikkelit

Kiiskinen T, Mars NJ, Palviainen T, Koskela J, Rämö JT, Ripatti P, Ruotsalainen S; FinnGen, GSCAN Consortium, Palotie A, Madden PAF, Rose RJ, Kaprio J, Salomaa V, Mäkelä P, Havulinna AS, Ripatti S. Genomic prediction of alcohol-related morbidity and mortality. Transl Psychiatry. 2020 Jan 21;10(1):23. PMID: 32066667

Mars N, Koskela JT, Ripatti P, Kiiskinen TTJ, Havulinna AS, Lindbohm JV, Ahola-Olli A, Kurki M, Karjalainen J, Palta P; FinnGen, Neale BM, Daly M, Salomaa V, Palotie A, Widén E, Ripatti S. Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nat Med. 2020 Epub Apr 7. PMID: 32273609

Ripatti P, Rämö JT, Mars NJ, Fu Y, Lin J, Söderlund S, Benner C, Surakka I, Kiiskinen T, Havulinna AS, Palta P, Freimer NB, Widén E, Salomaa V, Tukiainen T, Pirinen M, Palotie A, Taskinen MR, Ripatti S; FinnGen. Polygenic Hyperlipidemias and Coronary Artery Disease Risk. Circ Genom Precis Med. 2020 Apr;13(2):e002725. PMID: 32154731

Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020 Aug 6;107(2):211-221. PMID: 32649856

Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y. Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan. Nat Med. 2020 Epub Mar 23. PMID: 32251405

Tanigawa Y, Wainberg M, Karjalainen J, Kiiskinen T, Venkataraman G, Lemmelä S, Turunen JA, Graham RR, Havulinna AS, Perola M, Palotie A; FinnGen, Daly MJ, Rivas MA. Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. PLoS Genet. 2020 May 5;16(5):e1008682. PMID: 32369491

Vuori MA, Laukkanen JA, Pietilä A, Havulinna AS, Kähönen M, Salomaa V, Niiranen TJ; FinnGen investigators. The validity of heart failure diagnoses in the Finnish Hospital Discharge Register. Scand J Public Health. 2020 Feb;48(1):20-28. PMID: 31068116